Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and 1 diastolic dysfunction 2 3 4

Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and 1 diastolic dysfunction 2 3 4 Julien MAIZEL1,3, Sandhya XAVIER3, Jun CHEN3, Chi Hua Sarah LIN3, Radovan VASKO1,2, 5 Michael S GOLIGORSKY3 6 7 1Medical Intensive Care Unit, Department of Nephrology and INSERM U-1088, University of 8 Picardie, Amiens, France, 2Department of Nephrology and Rheumatology, University 9 Medical Center, Gottingen, Germany and 3Department of Medicine, Renal Research Institute, 10 New York Medical College, Valhalla, New York, USA 11 12 Address correspondence/reprint requests to: 13 Dr Julien Maizel 14 Medical Intensive Care Unit 15 Amiens University Hospital 16 80000 Amiens 17 France 18 Phone: +33 3 22455664 19 Fax: +33 3 22455854 20 Email: [email protected] 21 22 23 Running Title: Sirtuin 1 in cardiomyopathy of aging 24 25 26